6. 2.5 pts. Label the key viral and cellular factors in the indicated areas of the diagram (adapted from White & Schornberg, 2012). (Apply)
7. 2.5 pts. Formulate a hypothesis as to why there is more than one mechanism of viral entry into host cells. Which mechanism does Ebola virus use? (Create)
8. 2.5 pts. What are the three main mechanisms for viral release from a host cell? Which mechanism does Ebola virus use?
9. 2.5 pts. ZMapp consists of three antibodies against Ebola virus. Which of the following is true? Circle all that apply.
a. It is a vaccine.
b. It is a drug to be given post-exposure.
c. The antibodies each target different viral proteins.
d. The antibodies all target GP.
e. It is an antibiotic.
10. 5 pts. A new filamentous virus is identified deep in the forests of Africa and named Zambezi virus. In the extracellular
viral particle, it has a protein (S) at the surface that is important for binding to the host cell, a protein (E) that is found
under the lipid envelope and seems to be important during assembly and in maintaining the virus particle structure,
and another protein (R) that helps replicate the negative-strand RNA and generate positive-strand mRNAs. Due to its
similarities to Ebola and Marburg viruses, it is classified as a filovirus. For each of the proteins, identify the protein that
serves a similar function for the Ebola virus. Options include: GP, (-)ssRNA, VP40, L, lipid. (Analyze)